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Blockade of biogenic amine synthesis: its effect on the responses to leptazol and dexamphetamine in rats
Author(s) -
SPENCER P. S. J.,
TURNER T. A. R.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb09526.x
Subject(s) - dopamine , chemistry , long term potentiation , amphetamine , blockade , pharmacology , dihydroxyphenylalanine , dextroamphetamine , biogenic amine , neuroscience , neurotransmitter , biochemistry , medicine , biology , receptor
1 . The convulsive effects of leptazol in the rat are potentiated by prior treatment with dexamphetamine. 2 . An intact dopamine synthesis is necessary for the potentiation of the convulsive action of leptazol. 3 . An intact noradrenaline synthesis is not necessary for this action of amphetamine, as long as the dopamine synthesis is intact. 4 . An intact 5‐hydroxytryptamine synthesis is not necessary for the potentiation to be shown. 5 . Blockade of either noradrenaline, dopamine or 5‐hydroxytryptamine synthesis has no direct effect on leptazol convulsions. 6 . It is possible that it is an intact 3–4 dihydroxyphenylalanine (dopa) synthesis rather than an intact dopamine synthesis that is involved.