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The effects of iproniazid and reserpine on the accumulation of granular vesicles and noradrenaline in constricted adrenergic nerves
Author(s) -
BANKS P.,
KAPELLER K.,
MAYOR D.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb09516.x
Subject(s) - iproniazid , reserpine , vesicle , adrenergic , norepinephrine , cats , chemistry , constriction , electron microscope , ultrastructure , medicine , endocrinology , anatomy , biology , biochemistry , monoamine oxidase , physics , receptor , membrane , dopamine , optics , enzyme
1 . The accumulation of granular vesicles proximal to a constriction applied to hypogastric nerves has been investigated with the electron microscope in cats treated with reserpine and/or iproniazid. 2 . The ultrastructural changes have been correlated with the accumulation of noradrenaline at the same site in similarly treated animals. 3 . The findings give further support to the view that granular vesicles constitute a major storage site for intraneuronal noradrenaline.