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The relevance of β‐receptor blockade to ouabain‐induced cardiac arrhythmias
Author(s) -
DOHADWALLA A. N.,
FREEDBERG A. S.,
WILLIAMS E. M. VAUGHAN
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb09503.x
Subject(s) - propranolol , ouabain , blockade , pharmacology , repolarization , medicine , quinidine , potency , chemistry , electrophysiology , ventricular fibrillation , anesthesia , receptor , cardiology , sodium , in vitro , biochemistry , organic chemistry
1 . (+)‐propranolol and (±)‐propranolol are comparable in their potency as a local anaesthetic on the intact and desheathed frog sciatic nerve. 2 . (±)‐propranolol is much more potent than (+)‐propranolol as a β‐receptor blocking agent and also more effective than the latter in protecting guinea‐pigs against ouabain‐induced ventricular fibrillation. 3 . In isolated rabbit atria (–)‐, (+)‐ and (±)‐propranolol, and I.C.I. 50172, which has hardly any local anaesthetic activity, greatly reduce the rate of rise of the intracellularly recorded action potential at concentrations which have no significant effect on electrical threshold, contractions, spontaneous frequency, maximum driving frequency, repolarization time or conduction velocity.