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Carbon tetrachloride metabolism in the rabbit
Author(s) -
FOWLER J. S. L.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb08512.x
Subject(s) - carbon tetrachloride , chloroform , chemistry , metabolism , stomach , chromatography , gas chromatography , kidney , carbon 14 , biochemistry , organic chemistry , biology , endocrinology , physics , quantum mechanics
1 . Carbon tetrachloride was administered by stomach tube to rabbits and its distribution in fat, liver, kidney and muscle studied by gas liquid chromatography, during the next 48 hr. 2 . Chloroform, hexachloroethane and two unidentified chlorinated metabolites were detected in the tissues. 3 . Hexachloroethane may arise by dimerization of free trichloromethyl radicals.