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Prostaglandins A 1 , A 2 and 19‐hydroxy A 1 ; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds
Author(s) -
HORTON E. W.,
JONES R. L.,
HOPKIN JUDY M.,
HORTON E. W.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb08509.x
Subject(s) - dilator , vasodilation , prostaglandin , medicine , endocrinology , prostaglandin e , blood pressure , vasodilator agents , smooth muscle , chemistry
1 . Prostaglandins A 1 , A 2 and 19‐hydroxy A 1 have qualitatively similar actions to prostaglandin E 1 on smooth muscle. 2 . The prostaglandins A have little activity on gastrointestinal, respiratory and reproductive smooth muscle but are potent depressors of the systemic arterial blood pressure of the dog, cat and rabbit. 3 . Our experiments support the view that the depressor action of the prostaglandins E and A is due to a direct dilator action on many peripheral vascular beds and not due to changes in nervous tone to these beds. 4 . A single passage through the pulmonary circulation of the cat or dog causes substantial loss of the vasodilator activity of prostaglandin E 1 but little if any loss of the vasodilator activity of the prostaglandins A. 5 . A single passage through the hepatic portal circulation of the cat causes substantial loss of the vasodilator activity of prostaglandins E 1 , A 1 and A 2 . 6 . The cat blood pressure and rat fundal strip would be a suitable combination for the parallel biological assay of the prostaglandins A 1 and A 2 .