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The release of prostaglandin E 1 from the rat phrenic nerve‐diaphragm preparation
Author(s) -
LAITY J. L. H.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb08508.x
Subject(s) - phenoxybenzamine , phrenic nerve , bretylium , chemistry , prostaglandin , stimulation , diaphragm (acoustics) , prostaglandin e , muscle contraction , contraction (grammar) , anesthesia , endocrinology , medicine , adrenergic , biochemistry , respiratory system , physics , receptor , acoustics , loudspeaker
1 . The release of prostaglandin E 1 from the rat phrenic nerve‐diaphragm preparation during tetanic contraction of the muscle in response to nerve stimulation is reported. Tentative identification of the prostaglandin depended on solvent extraction column and thin‐layer chromatography and parallel biological assay. 2 . Polar lipid substances were released from the preparation in the absence of nerve stimulation by (+)‐tubocurarine and noradrenaline. 3 . The output on nerve stimulation was not abolished by (+)‐tubocurarine, hemicholinium, bretylium or phenoxybenzamine added to the bath. 4 . The possible origin of these prostaglandins is discussed.