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The characteristics of acetylcholine release mechanisms in the auditory cortex
Author(s) -
HEMSWORTH B. A.,
MITCHELL J. F.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb08313.x
Subject(s) - acetylcholine , neuroscience , auditory cortex , psychology , biology , pharmacology
1 The characteristics of the acetylcholine (ACh) release mechanism have been studied in the auditory cortex of rabbits on stimulation of the ipsilateral medial geniculate nucleus. 2 On stimulation of the medial geniculate nucleus the mean release of ACh from the auditory receiving cortex was 6.1 times the spontaneous release; the mean release from other parts of the cortex was 2.2 times the spontaneous release. 3 The frequency of stimulation most effective in evoking ACh release was found to be 10/sec. 4 Both the spontaneous and evoked release of ACh were reduced by 40–65% in the absence of calcium from the solution bathing the auditory cortex, and increased by 15–25% when the calcium concentration in the bathing solution was doubled. 5 The presence of low concentrations of magnesium in the fluid bathing the cortex was essential for the optimal release of ACh, but high magnesium concentrations lowered this release. 6 The presence of triethylcholine (TEC) in the fluid bathing the auditory cortex reduced both the spontaneous and evoked release of ACh. This reduction was reversed in the presence of choline. 7 The effects of calcium, magnesium and TEC on the ACh release mechanism in the cerebral cortex and at the neuromuscular junction are compared.