Premium
The effects of anions on sodium transport
Author(s) -
CUTHBERT A. W.,
PAINTER ELISABETH,
PRINCE W. T.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb08307.x
Subject(s) - theophylline , sodium , chemistry , frog skin , chloride , choline , biophysics , choline chloride , medicine , inorganic chemistry , endocrinology , biochemistry , biology , organic chemistry
1 Substitution of chloride by isethionate reduces the short circuit current (SCC) and increases the potential of isolated frog skin. In sodium isethionate Ringer antidiuretic hormone and choline chloride increase the SCC, whereas theophylline is ineffective. 2 Frog skins treated on the outside with copper ions always show an increased potential when bathed in normal Ringer solution. The SCC may be moderately increased or decreased. 3 Theophylline increases skin thickness and cell volume in non‐short‐circuited skins. 4 The ways in which the theophylline‐induced increase in chloride permeability affects sodium transport is discussed, together with the requirements for a permeant anion in both short‐ and open‐circuited skins.