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Hypothermia following intraventricular injection of hemicholinium‐3 in rats
Author(s) -
SLATER P.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb08302.x
Subject(s) - hypothermia , acetylcholine , hexamethonium , choline , chemistry , pharmacology , cholinergic , phentolamine , neostigmine , hyperthermia , intraperitoneal injection , endocrinology , medicine , anesthesia , stimulation , biochemistry
1 In unanaesthetized rats, a dose of 50 μg of hemicholinium‐3 injected into the cerebral ventricles produced a prolonged hypothermia which was unaffected by the simultaneous administration of choline. This suggests that it was not due to inhibition of acetylcholine synthesis. 2 An intraperitoneal injection of 50 μg of hemicholinium‐3 also produced hypothermia which, however, was blocked by choline which suggests that it is due to inhibition of acetylcholine synthesis. 3 Hyoscine and hexamethonium did not block the hypothermia produced by intraventricular hemicholinium‐3, but some antagonism was obtained with phentolamine, imipramine and amphetamine. 4 When hemicholinium‐3 was administered intraventricularly to rats pretreated with desmethylimipramine, a lethal hyperthermia developed. 5 It is concluded that no central cholinergic mechanism is involved in the hypothermia of the rat resulting from an intraventricular injection of hemicholinium‐3.