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The relationship between tremor and change in brain acetylcholine concentration produced by injection of tremorine or oxotremorine in the rat
Author(s) -
COX B.,
POTKONJAK D.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb07988.x
Subject(s) - oxotremorine , acetylcholine , neuroscience , chemistry , medicine , endocrinology , psychology , muscarinic acetylcholine receptor , receptor
1 The relationship between tremor and change in brain acetylcholine concentration after the injection of tremorine or oxotremorine has been investigated in rats. 2 Tremorine produced a significant increase in whole brain acetylcholine and in tremor 5 min after injection. After this time tremor subsided but brain acetylcholine continued to increase. 3 Oxotremorine produced tremor within 30 sec. This became maximal within 5 min of injection and then declined rapidly. The brain acetylcholine concentration showed a significant increase 5 min after injection and continued to increase until 30 min afterwards.