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Sustained complete autonomic blockade
Author(s) -
HALMAGYI D. F. J.,
NEERING I. R.,
VARGA D.,
PULLIN JOY
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb07986.x
Subject(s) - blockade , atropine , medicine , anesthesia , circulatory system , shock (circulatory) , heart rate , respiratory system , pharmacology , blood pressure , receptor
1 A 3‐hr period of complete autonomic blockade was induced in anaesthetized sheep and dogs using a continuous intravenous infusion of trimetaphan camphorsulphonate and atropine. Circulatory, respiratory and metabolic parameters were studied over 24 hr or until the animal died, whichever came first. 2 After termination of the blockade all animals remained hypotensive and within a few hours all died in irreversible shock which was not accompanied by any of the otherwise characteristic respiratory or metabolic consequences of circulatory failure. 3 Administration of trimetaphan alone for a similar period was innocuous. 4 When during complete autonomic blockade a continuous infusion of dopamine or hypertensin was additionally administered mortality rate was halved but all survivors remained hypotensive.