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Behavioural and biochemical effects of 2‐(2,6‐dichlorophenylamino)‐2‐imidazoline hydrochloride (St 155) on the central nervous system
Author(s) -
LAVERTY R.,
TAYLOR K. M.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb07984.x
Subject(s) - chlorpromazine , chloral hydrate , hypoactivity , avoidance response , cns depression , pharmacology , medicine , anesthesia , depressant , sedative , endocrinology , chemistry , toxicity
1 St 155 (2‐(2,6‐dichlorophenylamino)‐2‐imidazoline hydrochloride) (0.1–2.5 mg/kg subcutaneously) in rats prolonged chloral hydrate sleeping time, inhibited exploratory activity, reduced rotarod performance and pain‐induced aggression; in rats and guinea‐pigs conditioned avoidance behaviour was inhibited. 2 In most experiments St 155 was 5–7 times more potent than chlorpromazine on a weight basis. In white rats St 155 and chlorpromazine were equi‐effective in inhibiting conditioned avoidance behaviour. St 155 was relatively less active than chlorpromazine in lowering body temperature. 3 Chronic treatment with St 155 resulted in a reduction of its hypotensive and sedative effects and caused irritability and spontaneous episodes of severe fighting in white rats. 4 St 155, at doses causing similar conditioned avoidance response inhibition, produced a significant increase in noradrenaline concentration in all brain regions except the striate. Radioisotope studies indicate an increase in noradrenaline storage without significant changes in metabolism.