Premium
Spontaneous and evoked release of neurotransmitter substances in the longitudinal muscle of the anterior mesenteric artery of the domestic fowl
Author(s) -
BOLTON T. B.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb07971.x
Subject(s) - physostigmine , endocrinology , medicine , acetylcholine , isoprenaline , cholinergic , neurotransmitter , stimulation , catecholamine , cholinergic fibers , chemistry , receptor , cholinergic neuron
1 Changes in length of the longitudinal muscle of the anterior mesenteric artery of the domestic fowl (LMAMA) were recorded isotonically. 2 The actions of physostigmine and hyoscine suggest that the tone of the LMAMA is dependent on a resting release of acetylcholine within the tissue. 3 Catecholamines inhibited the contractions obtained in response to stimulation of cholinergic nerves; this was a β‐receptor effect. After β‐receptor blockade, noradrenaline, but not isoprenaline, weakly facilitated the effects of stimulating cholinergic nerves. 4 In the presence of hyoscine, nicotine relaxed preparations of the LMAMA in which the tone had been raised with barium chloride. These relaxations were considered to be due to a release of catecholamine probably from sympathetic nerves.