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In vitro studies on the mechanism of kinin formation by trypanosomes
Author(s) -
BOREHAM P. F. L.
Publication year - 1968
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1968.tb08488.x
Subject(s) - kinin , kallikrein , in vitro , bradykinin , trypanosomiasis , enzyme , biochemistry , antigen , biology , african trypanosomiasis , chemistry , immunology , receptor
1 . An investigation into the mechanism of kinin release in trypanosomiasis has been made in vitro . 2 . Trypanosomes contain a low level of kininase but no kinin‐forming enzyme nor substrate for salivary kallikrein. 3 . The kininase activity in the plasma of infected rats does not differ from that of normal animals, and trypanosomes do not affect the breakdown of synthetic bradykinin by enzymes in the blood. 4 . In trypanosomiasis the kininogenase precursor in plasma is activated. The hypothesis is put forward that the antigen‐antibody complex may be involved in this.