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The effect of chlorpromazine on cerebral glucose, ATP, ADP, AMP and ATPase in the mouse
Author(s) -
CHOWDHURY A. K.,
SKINNER ANNETTE,
SPECTOR R. G.,
YAP S.L.
Publication year - 1968
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1968.tb07951.x
Subject(s) - chlorpromazine , atpase , adenosine triphosphate , adenosine , adenosine monophosphate , atp hydrolysis , adenosine diphosphate , adenosine triphosphatase , chemistry , medicine , endocrinology , biochemistry , enzyme , biology , platelet , platelet aggregation
1 Administration of chlorpromazine 10 mg/kg intraperitoneally to mice produced no alteration in cerebral adenosine triphosphate (ATP), adenosine diphosphate (ADP) or adenosine monophosphate (AMP). In these animals there was an increase in the glucose content of the supernatants of homogenates of liver and brain following acid hydrolysis. 2 Chlorpromazine 40 mg/kg intraperitoneally did not affect Mg ++ activated adenosine triphosphatase (ATPase) activity in the brain.