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The neuromuscular blocking action of a series of bicyclic bis‐onium esters
Author(s) -
MARSHALL I. G.
Publication year - 1968
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1968.tb07950.x
Subject(s) - onium , depolarization , bicyclic molecule , chemistry , neuromuscular blocking agents , block (permutation group theory) , stereochemistry , biophysics , biology , medicine , organic chemistry , anesthesia , ion , geometry , mathematics
1 Thirteen bicyclic dicholine esters have been tested on mammalian and avian skeletal muscle preparations. 2 One of the compounds exhibited depolarizing activity in all the preparations. 3 Three of the compounds exhibited depolarizing or dual‐blocking activity in avian and denervated mammalian preparations, but exhibited non‐depolarizing blocking activity in innervated mammalian preparations. 4 The remaining compounds exhibited non‐depolarizing blocking activity with evidence of an additional facilitatory action. 5 The activity exhibited was dependent upon the onium substituents and the structure of the bicyclic ring. 6 All the compounds exhibited a choline‐reversible block in the rapidly stimulated rat diaphragm preparation and six of them exhibited a secondary choline‐reversible block of the rapidly stimulated cat tibialis anterior muscle.