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The effects of intracerebroventricularly administered noradnamine and other sympathomimetic amines upon leptazol convulsions in mice
Author(s) -
JONES B. J.,
ROBERTS D. J.
Publication year - 1968
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1968.tb07946.x
Subject(s) - reserpine , tyramine , dopamine , octopamine (neurotransmitter) , endocrinology , medicine , chemistry , norepinephrine , pharmacology , serotonin , receptor
1 The influence of some intracerebroventricularly administered sympathomimetic amines on leptazol‐induced convulsions has been investigated. 2 Noradnamine and high doses of dopamine proved to be anticonvulsant and also antagonized the facilitative effects of reserpine. 3 Noradrenaline and octopamine also antagonized reserpine‐induced facilitation but were without effect on leptazol alone; by contrast tyramine and small doses of dopamine lowered the threshold for leptazol convulsions. 4 A possible interpretation of these results is presented.