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Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide
Author(s) -
ANDÉN N.E.,
CORRODI H.,
FUXE K.,
HÖKFELT T.
Publication year - 1968
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1968.tb07943.x
Subject(s) - lysergic acid diethylamide , stimulation , serotonin , chemistry , 5 ht receptor , receptor , 5 hydroxytryptophan , hallucinogen , lysergic acid , dopamine , pharmacology , spinal cord , endocrinology , tryptophan hydroxylase , central nervous system , medicine , neuroscience , biochemistry , biology , serotonergic
1 Lysergic acid diethylamide (LSD) and the 5‐hydroxytryptamine (5‐HT) precursor, 5‐hydroxytryptophan produced similar functional effects in rat spinal cord and brain to the 5‐hydroxytryptamine precursor 5‐hydroxytryptophan, which indicates that LSD stimulates central 5‐HT receptors. 2 By means of combined histochemical and biochemical techniques it was found that LSD reduced the turnover rate of brain and spinal cord 5‐HT, studied after inhibition of the tryptophan hydroxylase by α‐propyldopacet‐amide. The turnover of brain noradrenaline but not dopamine was somewhat accelerated. 3 The functional and chemical effects by LSD were related to dose and to time. They were not observed after the LSD analogues 2‐bromo‐LSD and methysergide. 4 The retardation of the 5‐HT turnover by LSD may be due to negative feed‐back mechanisms evoked by direct stimulation of the central 5‐HT receptors.