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Inhibition by antihistamines of the vascular permeability increase induced by bradykinin
Author(s) -
BECKER E. L.,
MOTA I.,
WONG D.
Publication year - 1968
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1968.tb07054.x
Subject(s) - bradykinin , vascular permeability , pharmacology , histamine , histamine antagonists , permeability (electromagnetism) , histamine h1 antagonists , chemistry , medicine , endocrinology , biochemistry , receptor , membrane
1 Mepyramine and triprolidine hydrochloride have a marked inhibitory effect on the local increase of vascular permeability induced by bradykinin. 2 The anti‐bradykinin effect of both antihistamines was species dependent, being evident in rabbits, rats and mice but not in guinea‐pigs.