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Antagonism of reserpine‐induced emesis in pigeons: a screening method for antidepressant activity
Author(s) -
DHAWAN K. N.,
GUPTA G. P.,
JAJU B. P.
Publication year - 1968
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1968.tb07047.x
Subject(s) - reserpine , antidepressant , pargyline , pharmacology , iproniazid , monoamine oxidase , tetrabenazine , antagonism , monoamine oxidase inhibitor , phenelzine , chemistry , medicine , dopamine , receptor , biochemistry , hippocampus , enzyme
1 Various antidepressant drugs and procedures have been studied against reserpine‐induced emesis in pigeons. 2 Electroconvulsions, pentylenetetrazol and a non‐hydrazide monoamine oxidase inhibitor (pargyline) block reserpine emesis. 3 It is suggested that reserpine‐induced emesis in pigeons provides a simple and reliable method for studying anti‐reserpine activity, and the compounds effective in antagonizing this emetic response are likely to have antidepressant property.