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INVESTIGATION INTO THE MODE OF ACTION OF HISTAMINE ON THE ISOLATED RABBIT HEART
Author(s) -
DEAN P. M.
Publication year - 1968
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1968.tb00430.x
Subject(s) - clinical pharmacology , action (physics) , histamine , histamine receptor , citation , medicine , pharmacology , receptor , library science , computer science , physics , quantum mechanics , antagonist
Dale and Laidlaw, in 1910, showed that histamine increased the contractions of the isolated rabbit heart. From the perfusate of a heart stimulated by histamine, Went, Varga, Szucz & Fehdr (1954) collected a substance which diminished the spontaneous contractions of the rabbit duodenum, relaxed rat uterus and contracted the cat nictitating membrane; they attributed these effects to an adrenaline-like substance released from the heart. Mannaioni (1960) showed that diphenhydramine reduced the stimulant effect of histamine on the rate and force of contraction but did not affect the response of guinea-pig atria to adrenaline. Dichloroisoproterenol abolished the stimulant effect of noradrenaline; it also significantly reduced the response to histamine. There was no decrease in the response to histamine with atria depleted of catecholamines by pretreatment of the animals with reserpine (Trendelenburg, 1960). Mepyramine and pyribenzamine antagonized the stimulant effect of histamine on guinea-pig atria, although the pA2 value for mepyramine-histamine antagonism-about 5-was lower than that for guinea-pig ileum, which was about 9. From this evidence Trendelenburg concluded that cardiac histamine receptors differ from those found in smooth muscle. In contrast with these results, Bartlet (1963) found that mepyramine and diphenhydramine did not antagonize the action of histamine on the guinea-pig heart. In the present work an attempt has been made to resolve this conflicting evidence, first by trying to detect whether histamine does release sympathomimetic amines from the rabbit heart, and second by studying the mode of action of histamine on atria in order to investigate the interrelationship between the cardiac histamine and noradrenaline receptors.