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THE CENTRAL STIMULANT PROPERTIES OF SOME SUBSTITUTED INDOLYLALKYLAMINES AND β‐CARBOLINES AND THEIR ACTIVITIES AS INHIBITORS OF MONOAMINE OXIDASE AND THE UPTAKE OF 5‐HYDROXYTRYPTAMINE
Author(s) -
LESSIN A. W.,
LONG R. F.,
PARKES M. W.
Publication year - 1967
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1967.tb01940.x
Subject(s) - monoamine oxidase , library science , chemistry , computer science , biochemistry , enzyme
Some central stimulant properties of a-methyltryptamine and related compounds have been explained as due to an increased effectiveness of brain amines by a combination of interference with their storage and inhibition of their destruction by monoamine oxidase (Lessin, Long & Parkes, 1965a). A number of related indolylalkylamines and some pl-carbolines related to harmaline have been examined for these two properties and this paper considers how far the results may account for the distribution of stimulant activities in the two series. Some properties of a few of the indolylalkylamine derivatives studied here were previously reported by other workers (Greig, Walk & Gibbons, 1959; Tedeschi, Tedeschi, Fowler, Green & Fellows, 1962; Whittle & Young, 1963; Hester, Greig, Anthony, Heinzelman & Szmuszkovicz, 1964). The monoamine oxidase inhibitory properties of some of the 8-carbolines have been reported by Udenfriend, Witkop, Redfield & Weissbach (1958) and Pletscher, Besendorf, Bachtold & Gey (1959).