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EFFECTS OF REICHSTEIN'S COMPOUND S, STRYCHNINE AND LEPTAZOL PERFUSED THROUGH CEREBRAL VENTRICLES OF CATS
Author(s) -
FELDBERG W.,
REIT E.,
HALL G. H.
Publication year - 1966
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1966.tb01884.x
Subject(s) - mill , medicine , research council , library science , management , engineering , government (linguistics) , mechanical engineering , linguistics , philosophy , computer science , economics
Methods recently developed for perfusing the cerebral ventricles in the anaesthetized cat have made it possible to investigate the action of drugs on the nervous structures contained in the walls of the cerebral ventricles. With these methods tubocurarine was found to produce a number of central excitatory effects, some of which resulted from an action on structures in the walls of the third ventricle; others from an action on structures in the walls of either the anterior or the inferior horn of the lateral ventricle (Carmichael, Feldberg & Fleischhauer, 1962, 1964; Feldberg & Fleischhauer, 1962, 1965). None of these effects occurs when tubocurarine is injected intravenously because it does not cross the blood-brain barrier, or at least not in sufficient amounts. In the present experiments the cerebral ventricles of the cat were perfused with either Reichstein's compound S (17a-hydroxy-l1-desoxycorticosterone), strychnine or leptazol, three substances which are able to cross the blood-brain barrier and produce convulsions when injected intraperitoneally or intravenously. The experiments were undertaken to determine what central effects are produced when these convulsants are confined in their action to the walls of the cerebral ventricles, and to what extent these effects contribute to the convulsive activity observed on their intraperitoneal or intravenous injection. In addition, the effect of hippocampal activation on the seizure threshold for intravenous leptazol was investigated.