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EFFECTS OF AMPHETAMINE ON THE RESPONSES OF THE GUINEA‐PIG ISOLATEP VAS DEFERENS PREPARATION TO HYPOGASTRIC, NERVE STIMULATION
Author(s) -
EDGE N. D.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb02046.x
Subject(s) - vas deferens , hypogastric nerve , hexamethonium , amphetamine , guinea pig , stimulus (psychology) , stimulation , medicine , endocrinology , chemistry , anesthesia , psychology , dopamine , psychotherapist
In concentrations from 1 to 100 μg/ml., amphetamine potentiated responses of the isolated vas deferens preparation of the guinea‐pig stimulated via the hypogastric nerve at rates of from 5 to 40 shocks/sec. Potentiation was more pronounced with low than with high stimulus frequencies. A concentration of 500 μg/ml. of amphetamine had a blocking action which was more pronounced at high than at low stimulus frequencies. This effect contrasted with the ganglionic blocking action of hexamethonium which had a greater effect at low than at high stimulus frequencies.