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THE RESPIRATORY ACTION OF DICHLORPHENAMIDE
Author(s) -
DOYLE D.,
HARRIS E. A.,
SLAWSON K. B.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb02028.x
Subject(s) - respiration , respiratory system , acidosis , respiratory acidosis , drug , metabolic acidosis , ventilation (architecture) , medicine , anesthesia , carbon dioxide , pharmacology , chemistry , anatomy , mechanical engineering , organic chemistry , engineering
The action of dichlorphenamide has been investigated in three healthy subjects. After this drug had been given, ventilation increased while alveolar and oxygenated mixed venous P co 2 both fell. The magnitude of these changes was closely related to the degree of acidosis produced by the drug. The effect of intravenous acetazol‐amide, tested in one subject, was qualitatively similar to that of orally administered dichlorphenamide. Respiratory responses to carbon dioxide were studied in two of the subjects and in one of them the metabolic acidosis was sufficient to account for the short‐term effect of dichlorphenamide on respiration.