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PRODUCTION OF HERITABLE PARTIAL STERILITY IN THE MOUSE BY METHYL METHANESULPHONATE
Author(s) -
JACKSON H.,
PARTINGTON M.,
WALPOLE A. L.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb01607.x
Subject(s) - sterility , dominant lethal , mating , fertility , biology , genetics , physiology , andrology , toxicology , medicine , population , environmental health
Partial sterility, in the sense of reduced reproductive capacity, has been demonstrated in the F 1 progeny of male mice mated in the second week after a single dose of methyl methanesulphonate (50 mg/kg, intraperitoneally) with females of proved fertility. Sterility, both partial and complete, was encountered in the F 2 generation obtained by mating F 1 males and females with fertile partners. These results show that the compound, in a substerilizing dose, is capable of producing transmissible genetic damage. It is suggested that the procedure used is a practicable method of testing drugs for possible genetic effects.