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INHIBITORS OF HISTAMINE CATABOLISM AND THE ACTION OF GASTRIN IN THE RAT
Author(s) -
AMURE B. O.,
GINSBURG M.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb01604.x
Subject(s) - gastrin , histamine , iproniazid , medicine , chemistry , endocrinology , g cell , monoamine oxidase , diamine oxidase , stomach , chlorpromazine , gastric acid , secretion , biology , biochemistry , enzyme
A method is described for the partial purification of hog's antral gastrin by gel filtration and ion‐exchange chromatography. Gastrin was assayed by its effect on the pH of the effluent fluid from the perfused lumen of the stomach of the anaesthetized rat. The latency of the response to gastrin given intravenously was shorter than the latency to a similar dose of histamine. The response to gastrin injected into the arterial circulation of the stomach appeared sooner than the response to gastrin injected intravenously. Iproniazid and aminoguanidine potentiated responses to gastrin. Incubation in vitro with monamine oxidase or diamine oxidase did not inactivate gastrin. Chlorpromazine and bromolysergic acid diethylamide, in doses which enhance the effects of histamine on acid gastric secretion, did not affect responses to gastrin.