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POSSIBLE RELATIONSHIP BETWEEN TETRACYCLINE STABILITY AND EFFECT ON FOETAL SKELETON
Author(s) -
TUBARO E.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb01601.x
Subject(s) - tetracycline , skeleton (computer programming) , medicine , biology , physiology , anatomy , antibiotics , genetics
A possible relationship between stability of a tetracycline and persistence in the foetal skeleton is discussed; it seems that the greater the stability of a tetracycline, the more it may interfere with bone‐forming processes. Therefore, assuming that limited instability does not impair antibiotic potency in vivo , the use of a low‐stability tetracycline seems to be a safer form of treatment in order to avoid undesired effects on the foetal skeleton.