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INHIBITION OF SYMPATHOMIMETIC EFFECTS ON THE HEART
Author(s) -
BENFEY B. G.,
VARMA D. R.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb01596.x
Subject(s) - tyramine , ephedrine , amphetamine , chemistry , sympathomimetics , sympatholytics , pharmacology , blockade , antagonism , receptor , propranolol , endocrinology , medicine , biochemistry , dopamine
The adrenaline β‐receptor blocking drug, pronethalol, and the sympathomimetic amines, (–)‐ephedrine, (–)‐amphetamine, dexamphetamine, (–)‐Ω‐ephedrine and tyramine, inhibited the sympathomimetic effects of butyrylcholine and tyramine on the guinea‐pig isolated atrium. Being reversible and noncompetitive, this antagonism was unspecific and not due to blockade of adrenaline receptors, although pronethalol inhibited the effect of noradrenaline competitively.