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CENTRAL CARDIOVASCULAR ACTIONS OF γ‐AMINOBUTYRIC ACID
Author(s) -
BHARGAVA K. P.,
BHATTACHARYA S. S.,
SRIMAL R. C.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb01594.x
Subject(s) - vasomotor , ganglionectomy , cats , medicine , anesthesia , reflex , vagotomy , bradycardia , vertebral artery , endocrinology , heart rate , blood pressure , anatomy , alternative medicine , pathology
The vasomotor and cardiac effects of γ‐aminobutyric acid (GABA) administered by different routes were studied in cats and dogs. The cat was resistant to the action of GABA administered intravenously or into a vertebral artery. Intrathecal injection of GABA into the cat depressed the vasomotor reponse to spinal compression. In dogs, intravenous, intrathecal or intraventricular injection, or topical application of GABA to the floor of 4th ventricle consistently produced hypotension and depressed the reflex and direct excitability of the vasomotor neurones, located at the supraspinal and spinal levels. Bradycardia observed after intravenous and intraventricular injections of GABA into dogs was abolished by stellate ganglionectomy but not by vagotomy. It has been attributed to depression of the central sympathetic neurones.