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THE DEMONSTRATION OF THE SITE OF ACTION OF THE ANTIMETABOLITE DRUG 6‐AZAURIDINE BY THE USE OF LEUCOCYTE CULTURES
Author(s) -
BUTTOO A. S.,
ELVES M. W.,
ISRAËLS M. C. G.,
ROATH O. S.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb01569.x
Subject(s) - antimetabolite , drug , action (physics) , site of action , pharmacology , medicine , drug action , chemotherapy , physics , quantum mechanics
The ability of the lymphocyte cultured in vitro to transform and synthesize deoxyribonucleic has been utilized to locate the site of action of a new antimetabolite 6‐azauridine which acts by inhibiting nucleic acid synthesis. The exact site can be demonstrated by incorporating into the cultures nucleotides occurring distal and proximal to the presumed site of action of 6‐azauridine.