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ACTIONS OF PROSTAGLANDINS E 1 , E 2 AND E 3 ON THE CENTRAL NERVOUS SYSTEM
Author(s) -
HORTON E. W.
Publication year - 1964
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1964.tb01558.x
Subject(s) - stupor , sedation , anesthesia , cats , reflex , catatonia , medicine , righting reflex , central nervous system , respiratory system , vomiting , schizophrenia (object oriented programming) , psychiatry
Prostaglandins E 1 , E 2 and E 3 , injected into the cerebral ventricles of unanaesthetized cats, produced sedation, stupor and signs of catatonia. The threshold dose was 3 μg/kg. Slight sedation was also observed following an intravenous injection, but a dose of 20 μg/kg was required. In chicks, intravenous injections of prostaglandins (10 to 400 μg/kg) caused respiratory depression, profound sedation, loss of normal posture and, with the higher doses, loss of the righting reflex.