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THE EFFECT OF CERTAIN ETHYLENEIMINES ON RENAL FUNCTION
Author(s) -
JACKSON H.,
JAMES R. M. V.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb02025.x
Subject(s) - ethyleneimine , diuresis , chemistry , sodium , potassium , in vivo , pharmacology , endocrinology , renal function , medicine , biochemistry , biology , organic chemistry , microbiology and biotechnology , polymer
Certain simple derivatives of ethyleneimine cause an intense and prolonged diuresis in nonhydrated rats. Sodium, potassium and chloride excretion is unaffected by these compounds. Ethyleneimine also causes a diuresis in the rat, but the poly‐functional compound thiotepa is ineffective. The relationship between structure and activity of a number of compounds is discussed with particular reference to the possibility that the diuresis is due to the in vivo liberation of ethyleneimine.