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PRESENCE OF KALLIKREIN IN THE γ‐GLOBULIN PERMEABILITY FACTOR OF GUINEA‐PIG SERUM
Author(s) -
DAVIES G. E.,
LOWE J. S.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb02017.x
Subject(s) - guinea pig , globulin , chemistry , kallikrein , chromatography , albumin , esterase , bovine serum albumin , hydrolysis , permeability (electromagnetism) , serum albumin , biochemistry , gamma globulin , endocrinology , biology , enzyme , immunology , antibody , membrane
γ‐Globulin fractions isolated from guinea‐pig serum by chromatography on diethyl‐aminoethyl cellulose exhibited all the properties of kallikrein. From a range of amino acid esters tested, only esters of arginine and lysine were hydrolysed; the esterase and capillary permeability‐increasing activities of different samples were correlated. Both esterase and permeability‐increasing activities could be increased by the addition of certain albumin‐rich fractions or of glass beads previously treated with guinea‐pig serum.