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AN ANTIHISTAMINE‐LIKE SUBSTANCE (OR SUBSTANCES) IN EXTRACTS PREPARED FROM HUMAN TISSUES
Author(s) -
KOVACS B. A.,
PELLETIER G.,
ROSE B.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb02009.x
Subject(s) - antihistamine , histamine , bradykinin , substance p , ileum , in vitro , guinea pig , pharmacology , chemistry , histamine h1 antagonists , uterus , eledoisin , medicine , endocrinology , biochemistry , receptor , neuropeptide
A method for the extraction of an antihistamine‐like substance (or substances) from human tissues is described. The method has demonstrated the presence of this active principle(s) in a large variety of human tissues, so far without exception. The substance(s) has a wide range of activity in antagonizing the in vitro effects of histamine, 5‐hydroxytryptamine and bradykinin and the Schultz‐Dale reaction on the guinea‐pig ileum and rat uterus preparations.