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THE EFFECTS OF CHOLINE AND OTHER FACTORS ON THE RELEASE OF ACETYLCHOLINE FROM THE STIMULATED PERFUSED SUPERIOR CERVICAL GANGLION OF THE CAT
Author(s) -
MATTHEWS E. K.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb01523.x
Subject(s) - acetylcholine , physostigmine , choline , superior cervical ganglion , perfusion , stimulation , endocrinology , medicine , chemistry , cholinergic , ganglion , atropine , anatomy , biology
When the superior cervical ganglion of the cat was perfused with Locke solution, the amount of acetylcholine released into the perfusate decreased during successive periods of repetitive stimulation of the preganglionic nerve. Addition of choline to the perfusion fluid prevented this decrease. Choline also significantly increased ( P >0.01) the initial output of acetylcholine. In contrast, variation of the physostigmine concentration or of the p CO 2 and p H of the perfusion fluid had no statistically significant effect ( P >0.05) upon the initial release of acetylcholine.