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PLASMA VOLUME EXPANSION BY RAPID INFUSION OF A LOW MOLECULAR WEIGHT DEXTRAN
Author(s) -
DAVIES J. W. L.,
RICKETTS C R.,
WILLIAMS B. N.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb01519.x
Subject(s) - dextran , volume (thermodynamics) , plasma volume , cerebrospinal fluid , chemistry , volume expansion , blood volume , intravascular volume status , excretion , medicine , endocrinology , anesthesia , chromatography , hemodynamics , physics , quantum mechanics
Large infusions of a 10% solution of dextran of molecular weight 40,000 were given to dogs during 3 min using a specially designed apparatus. The initial expansion of plasma volume was about twice the volume of solution injected. Plasma volume then fell rapidly (with a half life of about 2 hr), more rapidly than the fall in dextran concentration (half‐life of about 4.5 hr). Fluctuations in plasma volume and protein concentration were repeatedly observed during the return towards normal values. At 5 to 6 hr renal excretion accounted for 40% of the infused dextran, about 20% was intravascular and the remaining 40% was presumably extra vascular. No dextran was found in the cerebrospinal fluid.