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THE RELATION BETWEEN UROGASTRONE AND GONADOTROPHINS
Author(s) -
PERERA B. A. V.,
ROSENOER V. M.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb01490.x
Subject(s) - toad , endocrinology , medicine , carbachol , secretion , chemistry , inhibitory postsynaptic potential , biology , stimulation
A commercial preparation of chorionic gonadotropin inhibited gastric acid secretion induced by carbachol in rats. When the preparation was incubated for 10 min at 100° C and p H 7, its gonadotrophic activity, as measured by a simple quantal assay based on the male toad spermiation response, was reduced by 92%. The inhibition of gastric acid secretion by the preparation was not significantly reduced by this treatment. It is concluded that the two activities are separable.