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IONTOPHORETIC RELEASE OF ADRENALINE, NORADRENALINE AND 5‐HYDROXYTRYPTAMINE FROM MICROPIPETS
Author(s) -
KRNJEVIĆ K.,
LAVERTY R.,
SHARMAN D. F.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb01485.x
Subject(s) - iontophoresis , pipette , chemistry , adrenergic , norepinephrine , anesthesia , epinephrine , biophysics , chromatography , endocrinology , medicine , biology , neuroscience , dopamine , biochemistry , receptor
Estimations have been made of the amounts of adrenaline, noradrenaline and 5‐hydroxytryptamine released by iontophoresis from micropipettes. In most experiments, the amount released was linearly related to the total electrical charge, but the transport numbers for different pipettes, filled with samples of the same solutions of adrenaline or of noradrenaline, varied substantially. Two pipettes containing noradrenaline failed to release any appreciable amounts of the drug. The transport number of 5‐hydroxytryptamine was relatively constant (mean, 0.14).