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ACTIONS OF TWO ALDOSTERONE ANTAGONISTS ON CAT PERFUSED KIDNEYS
Author(s) -
LOCKETT MARY F.,
ROBERTS C. N.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb01481.x
Subject(s) - aldosterone , spironolactone , chemistry , endocrinology , medicine , potassium , renal blood flow , sodium , renal function , kidney , pharmacology , organic chemistry
The actions of a closed‐ring [spironolactone, SC‐9420, β‐(7α‐acetylthio‐17β‐hydroxy‐3‐oxoandrost‐4‐en‐17α‐yl)propionic acid lactone] and of an open‐ring [SC‐11480, potassium β‐(17β‐hydroxy‐3‐oxoandrosta‐1,4‐dien‐17α‐yl)propionate] spirolactone have been examined on the cat perfused kidney, in concentrations ranging from 5 to 20 mg per 150 ml. of blood. Both compounds had weak aldosterone‐like effects and caused antidiuresis with retention of sodium, potassium and chloride. The urinary changes they induced summed with those of aldosterone, without competition. Neither spironolactone nor SC‐11480 affected renal blood flow or glomerular filtration rate. Both compounds antagonized the reduction in renal vascular resistance caused by aldosterone in these preparations.