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STIMULUS FREQUENCY AND NEUROMUSCULAR BLOCK
Author(s) -
BLACKMAN J. G.
Publication year - 1963
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1963.tb01292.x
Subject(s) - stimulation , stimulus (psychology) , acetylcholine , neuromuscular junction , nerve stimulation , electric stimulation , chemistry , anesthesia , neuroscience , medicine , biology , psychology , psychotherapist
Muscle twitches of the rat isolated diaphragm and frog sartorius preparations were recorded. It was confirmed that, in the presence of tubocurarine, the degree of neuromuscular block was greater the higher the frequency of stimulation. The results suggest that the quantity of acetylcholine released by each nerve impulse was reduced by increasing the rate of stimulation so that, in a tubocurarine solution, muscle fibres which were only just being fired at a slow rate of stimulation failed to fire at a faster rate.