Premium
EFFECT OF CHLORPROMAZINE, RESERPINE, BENACTYZINE AND PHENOBARBITONE ON THE RELEASE OF CORTICOTROPHIN IN THE RAT
Author(s) -
ASHFORD A.,
SHAPERO M.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01450.x
Subject(s) - chlorpromazine , reserpine , adrenocorticotropic hormone , pharmacology , stimulant , chemistry , phenobarbital , hydrocortisone , medicine , endocrinology , hormone
A single injection into the rat of chlorpromazine, reserpine, benactyzine or phenobarbitone stimulates the release of corticotrophin. This effect is not seen after the drugs have been injected daily for 5 days, nor when the rats are hypophysectomized or pretreated with hydrocortisone. The stimulant effect of ether on corticotrophin release is not modified by pretreatment with a single injection, nor to any great extent after 5 daily injections of these drugs.