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DEPRESSION OF MUSCLE SPINDLE ACTIVITY—A NEW TYPE OF PHARMACOLOGICAL ACTION?
Author(s) -
BEIN H. J.,
FEHR H.U.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01442.x
Subject(s) - action (physics) , neuroscience , muscle contraction , medicine , depression (economics) , biology , anatomy , physics , macroeconomics , quantum mechanics , economics
The effect of 2,4‐di(diethylamino)‐6‐(2‐phenylacetylhydrazino)‐1,3,5‐triazine (Ciba 28882‐Ba) injected intravenously on the activity of de‐efferented muscle spindles of the tibialis anterior and extensor digitorum longus muscles of anaesthetized cats, and on γ‐motoneurones of decerebrate cats, was investigated. The drug depressed both the static activity of muscle spindles and the spontaneous activity of γ‐motoneurones. In contrast, the response of muscle spindles to rapid stretch was not affected. The effect of 28882‐Ba on the activity of the muscle spindles resembled that of progressive unloading or shortening of the muscle. 28882‐Ba antagonized excitation of the muscle spindle by suxamethonium. The effect of 28882‐Ba on the response of the γ‐motoneurones to various driving stimuli was not predictable.