Premium
EFFECT OF ANTISYMPATHOMIMETIC DRUGS ON THE PLASMA CONCENTRATIONS OF CATECHOL AMINES
Author(s) -
WILLEY G. L.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01441.x
Subject(s) - dihydroergotamine , phenoxybenzamine , chloralose , cats , catechol , chemistry , ergotamine , ether , pharmacology , choline , anesthesia , medicine , biochemistry , organic chemistry , receptor , migraine
Intravenous injection of phenoxybenzamine, choline 2,6‐xylyl ether bromide (xylocholine, TM 10), piperoxane or dihydroergotamine increases the vasopressor activity of blood plasma, collected from cats under chloralose anaesthesia. The increased vasopressor activity that follows the administration of piperoxane is due to an increase of adrenaline and noradrenaline in the plasma. Cross‐circulation experiments show that catechol amines are liberated from the spleen by piperoxane.