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EFFECT OF ETHAMIVAN (VANILLIC ACID DIETHYLAMIDE) ON THE RESPIRATORY RESPONSE OF HEALTHY YOUNG MEN TO CARBON DIOXIDE, IN THE ABSENCE OF HYPOXIA
Author(s) -
ANDERTON J. L.,
COWIE J. F.,
HARRIS E. A.,
SLEET R. A.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01435.x
Subject(s) - respiration , stimulation , carbon dioxide , respiratory system , hypoxia (environmental) , vanillic acid , anesthesia , respiratory rate , medicine , pharmacology , physiology , chemistry , heart rate , oxygen , anatomy , organic chemistry , blood pressure
The effect of ethamivan (vanillic acid diethylamide) on the ventilatory response to carbon dioxide has been investigated in healthy young adult males. Intravenous infusion of the drug at a rate of 9 mg/min causes respiratory stimulation depending in degree upon the prevailing alveolar CO 2 tension. When the latter is low stimulation by the drug is most marked and may largely support respiration below the CO 2 threshold. As alveolar Pco 2 increases, the effect of the drug disappears. These findings are discussed.