Premium
EFFECTS OF SINGLE AND REPEATED DOSES OF RESERPINE ON THE SECRETION OF ADRENOCORTICOTROPHIC HORMONE
Author(s) -
MONTANARI R.,
STOCKHAM M. A.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01414.x
Subject(s) - reserpine , ascorbic acid , adrenocorticotrophic hormone , endocrinology , medicine , corticosterone , adrenocorticotropic hormone , hormone , secretion , adrenal gland , chemistry , food science
The effects of single and repeated doses of reserpine on the secretion of adreno‐corticotrophic hormone (ACTH) were studied in rats by determining changes in the adrenal and plasma concentrations of corticosterone, in the adrenal ascorbic acid levels, and in the adrenal gland weights. Treatment with doses of reserpine which induced sedation caused prolonged hypersecretion of ACTH. Such treatment did not impair the release of ACTH in response to a stressful stimulus as recorded by an increase in the plasma corticosterone even when there was no concomitant depletion in the adrenal ascorbic acid. This finding casts doubt on the value of the adrenal ascorbic acid determination as an index of ACTH secretion.