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TRYPANOCIDAL ACTION OF p ‐BIGUANIDOACETOPHENONE AMIDINOHYDRAZONE
Author(s) -
HAWKING F.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01196.x
Subject(s) - trypanocidal agent , trypanosomiasis , pharmacology , action (physics) , trypanosoma , suramin , biology , virology , trypanosoma brucei , in vitro , biochemistry , gene , physics , quantum mechanics
p ‐Biguanidoacetophenone amidinohydrazone, given in single doses, can cure mice infected with an old laboratory strain of Trypanosoma rhodesiense , but it has only slight action on more recently isolated strains. Trypanosomes which are resistant to stilbamidine are resistant to this compound also. Apparently its trypanocidal action is similar to that of the diamidine series of trypanocidal compounds.