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INHIBITION OF PLASMA KININASE ACTIVITY AT SLIGHTLY ACID pH
Author(s) -
EDERY H.,
LEWIS G. P.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01192.x
Subject(s) - bradykinin , chemistry , enzyme , biochemistry , kallikrein , medicine , endocrinology , biology , receptor
Kinins, like bradykinin, are rapidly inactivated in blood and interstitial fluid by an enzyme called kininase. The action of this enzyme was found to be inhibited at slightly acid p H although the formation of kinins proceeded normally. Thus a slightly acid p H which is known to occur in inflamed and damaged tissue is a suitable environment to allow accumulation of kinins which are thought to be the mediators of the inflammatory response.