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STIMULATION AND SENSITIZATION OF THE ISOLATED VENUS HEART BY CEREBROSPINAL FLUID
Author(s) -
BOWERS M. B.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01191.x
Subject(s) - cerebrospinal fluid , stimulation , reserpine , sensitization , amine oxidase , biogenic amine , serotonin , chemistry , medicine , pathology , amine gas treating , immunology , receptor , organic chemistry
5‐Hydroxytryptamine was not detected in animal cerebrospinal fluid after amine oxidase inhibitors, reserpine, or both. Both human and animal cerebrospinal fluid can produce a stimulating effect on the clam heart which is not due to 5‐hydroxytryptamine. Cerebrospinal fluid also has the property of increasing the sensitivity of the clam heart to 5‐hydroxytryptamine.