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A METHOD FOR THE QUANTITATIVE ESTIMATION OF DRUGS ON THE ISOLATED INTACT TRACHEA
Author(s) -
JAMIESON DANA
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01190.x
Subject(s) - histamine , acetylcholine , smooth muscle , chemistry , pharmacology , medicine , anesthesia
A method is described for the detection and comparison of substances active on tracheal smooth muscle. Several pharmacological agents affecting smooth muscle have been tested using the technique. Sensitivity was high, results reproducible and linear log dose‐response relationships obtained over a wide dosage range. The method has been used to estimate the concentrations of adrenaline, acetylcholine and histamine in test solutions of these compounds.